Comprehensive Control Measures of Porcine Circovirus Disease
Release time:
Aug 15,2018
Based on the current experience in controlling the disease around the world, the prevention and control measures include: appropriate active and passive immunization against co-infection sources, selective preventive dosing and treatment, and changes in production management measures. Because so farPCV-2The pathogens and mechanisms that cause related swine diseases are not fully understood, and therefore specific control measures cannot be fully relied on. Only by carrying out effective comprehensive prevention and control measures at the same time can we achieve better results.
1Immunization of known common source of infection
（1）PRRSVattenuated vaccine
PRRSVThe antibody titer and maintenance time produced by the inactivated vaccine are not as good as the weak vaccine, but the biological safety of the weak vaccine is controversial, and there have been reports of blue ear disease caused by the weak vaccine abroad.
（2）PPVVaccines
PPVAsPCV-2The common source of infection has been identified, but in fact it is generally scattered. The reason is that most of the sows have high antibodies. The effective duration of maternal antibodies in piglets can reach100days or so. withoutPCV-2Immunized gilts may have higher morbidity.
（3) Immunization of other possible common sources of infection
The disease spectrum of different farms is often not exactly the same. First, the farm should determine its own possible common pathogens in order to adopt appropriate vaccines and immunization procedures.
（41) Artificial passive immunity
There have been reports of rehabilitation serum treatment abroad. Shanghai and Zhejiang also have many pig farms trying to use serum to controlPCV-2However, the therapeutic effect of rehabilitation pig serum is often related to the selection of donor pigs, serum treatment, storage and use methods. In particular, the application of non-local serum has great security risks. The use of rehabilitation serum will affect the growth rate and will generally extend the time of slaughter.15days or so.
（5）“Infection”Active immunity to substances
“Infection”Substances, usually the manure of infected pigs, stillbirths, mummies, etc., used to feed sows, especially first-born sows. When there are highly pathogenic pathogens such as swine fever in pig farms, it will cause serious consequences, so safety assessment should be carried out before adoption.
（6) The effect of inactivated vaccine in their own tissues is often poor due to insufficient antigen concentration.
2Drug prevention and treatment
（1）Drugs, especially antibiotics, can only be used to control bacterial secondary infection, the effect of antiviral drugs is not exact, and the long-term application of antibiotics produces drug resistance and double infection.
（2）Mixing of different farms/Secondary infection of bacteria is not exactly the same, a single antibiotic can not completely cover all the bacteria to be controlled, so it must be used in combination. To date, many drugs and regimens have been unsatisfactory.
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