Causes and Countermeasures of Aggravated Reaction to Live Vaccine
Release time:
Jun 14,2018
Respiratory symptoms or swollen eyes, tears and other symptoms in the immune flock are in most farms.ZengIt happened. We call this symptom a vaccine reaction. After the live vaccine, the virus multiplies at the inoculation site,In healthy chickens in a good environment, the vaccine response caused by vaccine virus replication is mild, usually 3 to 5 days after immunization.Days are obvious, and continue for another 3 to 5 days. If the symptoms of the vaccine reaction are severe and the duration is prolonged, there are usually other factors at play.
Mechanisms of aggravating live vaccine reactions:
The live vaccine is immunized by eye drops and nasal drops, and then multiplies at the inoculation site, causing slight damage to the respiratory epithelium. For example, pathogenic bacteria with more pollution in the environment, such as Escherichia coli, Staphylococcus, Mycoplasma, Pseudomonas aeruginosa, etc., will take advantage of the deficiency to aggravate the vaccine reaction.
Causes of aggravated vaccine reactions:
1. Environmental factors: poor ventilation in chicken houses, dirty air, high density, and severe vaccine reactions often occur after immunization in chicken houses with poor hygiene.
2. Chickens constitution: Chickens are not healthy, such as the occurrence or latent infection of E. coli, slow-call chickens tend to show a heavier vaccine response after vaccination. InfectionChickens with immunosuppressive diseases often show a heavier vaccine response, such as chickens infected with the bursa of Fabricius after immunization with Newcastle disease freeze-dried vaccines or immune larynx freeze-dried vaccines, often show a heavier vaccine response.
3. Vaccines: large doses of vaccination,Vaccine virulent, non-SPF embryo-derived live vaccines often show a heavier vaccine response.
Prevention and control measures:
1. Try to ensure that the air in the chicken house is fresh, free of dust and harmful gases. The chicken flock density is reasonable. Provide the chickens with nutritionally complete feed.
2. If chickens are not immune under unhealthy conditions, antibiotics can be added to drinking water 3 days in advance to avoid vaccine reactions when special circumstances require immunization or when there are incentives that can lead to vaccine reactions in chickens, such as poor ventilation and high density.
3. The introduction of chicken fry from a good reputation, strong technical force, to avoid infection of egg-borne diseases. Do a good job in the immunization of bursal disease, try not to use virulent bursal vaccine.
4. It is recommended to use SPF embryo-derived live vaccine; attenuated vaccine can be selected for the first immunization, and vaccine with slightly stronger virulence can be used for the second immunization. Immunization shall be carried out in strict accordance with the instructions of the vaccine or under the guidance of technicians, and the dose shall not be increased at will. Infectious laryngotracheitis vaccine often causes swollen eyes, tears and other symptoms after eye injection. Penicillin and streptomycin can be added to the vaccine or inoculated with anal smear to reduce the reaction.
Treatment:
1. Eliminate incentives, such as strengthening ventilation and increasing nutrition.
2. Add vitamin and doxycycline in drinking water for 3-5 days.
3. For chickens with swollen eyes and tears, erythromycin eye drops can be used.
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